Clinical Significance of PCNA and nm23 Expression in Invasive Colorectal Carcinoma.

, Kang, Gu; , Park, Chul Jae

Original Article

Journal of the Korean Society of Coloproctology 2001;17(1):47-52.

¹Department of Pathology, Kangwon National University College of Medicine. guk@cc.kangwon.ac.kr
²Department of General Surgery, Hallym University College of Medicine, Seoul, Korea.

Abstract

PURPOSE
It is known that PCNA (proliferating cell nuclear antigen) is associated with cell proliferating activity and nm23 with so called 'anti-metastatic' activity. We tried to elucidate the relationships of PCNA labeling index and nm23 expression in carcinoma cells with survival rates of patients with invasive colorectal carcinoma.
METHODS
Immunohistochemical study was performed using monoclonal antibodies for PCNA and nm23 gene products on 45 cases of paraffin-embedded tissue made of invasive colorectal cancer.
RESULTS
Five-year survival rate was lower in the group with high PCNA labeling index than that with low one, but PCNA labeling index was not associated with the tumor stages. Expression of nm23 was not associated with survival rate, tumor stage, site, and PCNA labeling index.
CONCLUSIONS
Although PCNA labeling index was not associated with tumor stages, this study suggests that PCNA labeling index will be a good prognostic factors in invasive colorectal carcinoma.

Key Words: PCNA; nm23; Colorectal carcinoma