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Ann Coloproctol > Volume 25(2); 2009 > Article
Journal of the Korean Society of Coloproctology 2009;25(2):107-112.
DOI: https://doi.org/10.3393/jksc.2009.25.2.107   
Clinical Significance of p53 and Ki-67 Expression in Colorectal Cancer.
Huh, Jung Wook , Kim, Hyeong Rok , Cho, Sang Hyuk , Kim, Young Jin
Department of Surgery, Chonnam National University Hwasun Hospital and Medical School, Gwangju, Korea. drkhr@chonnam.ac.kr
Abstract
PURPOSE
This study aimed to evaluate the clinical significance of p53 and Ki-67 expressions in patients with colorectal cancer.
METHODS
Immunohistochemical expressions of p53 and Ki-67 in 205 patients with colorectal cancer were examined.
Results
were correlated with clinical and pathological parameters.
RESULTS
Overexpression of p53 was significantly associated with a proximal location of the tumor (P=0.031) and with lymph node involvement (P=0.030); however, Ki-67 expression was not correlated with any of the clinicopathological variables. Positive p53 staining was significantly associated with a higher level of Ki-67 (P=0.009).
CONCLUSIONS
Overexpression of p53 was strongly correlated with lymph node metastasis in colorectal cancer; thus, p53 may be used as a possible prognostic marker in patients with colorectal cancer.
Key Words: p53, Ki-67, Colorectal cancer


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