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Original Article
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J Korean Soc Coloproctol. 2007;23(2):71-74.
DOI: https://doi.org/10.3393/jksc.2007.23.2.71
- The Effect of Dexpanthenol in Postoperative Patients.
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Hwang, Mi Ri , Kim, Hungdai , Cho, Dong Ho , Han, Won Kon
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1Department of Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. hungdai.kim@samsung.com
- Abstract
- PURPOSE: The purpose of this study was to compare the efficacy of dexpanthenol in postoperative patients.
Dexpanthenol, the alcohol derivative of pantothenic acid, is believed to be a precursor of acetylcholine through its incorporation into coenzyme-A.
METHODS
From June 2005 to December 2005, 130 curative abdominal surgery, which were divided into a dexpanthenol group with 65 patients and a control group with 65 patients, were prospectively and randomly studied for recovery of bowel motility.
RESULTS
No significant difference was found between the two groups as to incidence of postoperative ileus (16.9% vs.
15.4%, P=0.081), the time to flatus (77.2+/-38.4 vs.
77.9+/-31.9 hours, P=0.90), the time to defecation (5.3+/-2.7 vs. 5.1+/-2.6 days, P=0.77), the time to resumption of meals (7.9+/-4.0 vs. 8.9+/-4.2 days, P=0.17), and the duration of hospital stay (16.4+/-7.8 vs.
17.9+/-11.5 days, P=0.39).
CONSLUSIONS: Since no differences in the postoperative bowel motility were observed between the two groups, dexpanthenol is not recommended for general surgical use.
Keywords :Dexpanthenol;Postoperative ileus
