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Original Article
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J Korean Soc Coloproctol. 1998;14(3):655-660.
- Small Flat Adenocarcinoma of the Colon Arising From Familial Adenomatous Polyposis Patient: Suggesting de novo Origin.
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Park, Dong Kook , Lee, Min Chol , Jun, Ho Jin , Lee, Chan Young , Kim, Jung Tak , Jung, Min , Park, Jong Kwon , Ryu, Jin Woo
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- Abstract
- Most adenocarcinomas of the colorectum arise in a visible benign precursor lesion, the adenoma, which is a monoclonal proliferation of dysplastic nonmalignant epithelial cells.
Adenoma-adenocarcinoma sequence has been represented as the predominat pathogenetic pathway. But a small flat depressed colon cancer is characterized by non-polypoid growth pattem with no association of adenomatous tissues, which has tendency to early submucosal invasion and lymph node metastasis even in very small lesion (<10 mm). It supports de novo carcinogenesis of colorectal cancer, although most colorectal cancerarise in pre-existing adenoma. We report a case of small float colon adenocarcinoma arising in normal colonic epithelium rather than adenomatous polyp in familial adenomatous polyposis syndrome.
Keywords :Small flat adenocarcinoma;Colon
