Warning: fopen(/home/virtual/colon/journal/upload/ip_log/ip_log_2025-01.txt): failed to open stream: Permission denied in /home/virtual/lib/view_data.php on line 95 Warning: fwrite() expects parameter 1 to be resource, boolean given in /home/virtual/lib/view_data.php on line 96 Anticancer Effects of IP6 in a Human Colon Carcinoma Cell Line in Nude Mice Xenografts.
Skip Navigation
Skip to contents

Ann Coloproctol : Annals of Coloproctology

OPEN ACCESS
SEARCH
Search
Advanced Search
mobile menu button

Articles

Page Path
HOME > J Korean Soc Coloproctol > Volume 26(2); 2010 > Article
Original Article
Anticancer Effects of IP6 in a Human Colon Carcinoma Cell Line in Nude Mice Xenografts.
Kim, Chan Dong , Lee, Jeong Eun , Lee, Ryung Ah , Kim, Kwang Ho
Journal of the Korean Society of Coloproctology 2010;26(2):93-97
DOI: https://doi.org/10.3393/jksc.2010.26.2.93
Department of Surgery and Institute for Medical Science, Ewha Womans University School of Medicine, Seoul, Korea. ralee@ewha.ac.kr
prev next
  • 2,282 Views
  • 19 Download
  • 0 Crossref
  • 0 Scopus
Full Article

Download PDF Download PDF

Abstract

PURPOSE
Inositol hexaphosphate (IP6) is a naturally occurring polyphosphorylated carbohydrate that has been shown to suppress the growth of epithelial cancer. Because IP6 is a dietary phytochemical present in cereals, soy, legumens, and fiber-rich foods, we evaluated the efficacy of IP6 against colon cancer formation.
METHODS
HT-29 cells were injected into nude mice. The animals were fed a normal diet (group 1), a low IP6 diet (group 2), and a high IP6 diet (group 3) for 4 wk. Body weight, tumor volume, tumor growth rate, growth inhibition rate, and therapeutic ratio were monitored after injection of HT-29 cells.
RESULTS
HT-29-cell human-colon-carcinoma xenograft mice treated with IP6 showed a significant reduction in tumor growth rate, irrespective of the IP6 dose compared to normal diet group. Compared with the control group, group 3 showed a significant reduction (45%) in tumor volume. In the therapeutic ratio gain profiles, IP6 diet groups showed a significant alteration of therapeutic ratio when compared with the normal diet group (0% vs. 11%, P=0.014). In the body weight gain profiles, group 3 showed a significant reduction of body weight compared with the other two groups (20.25 g vs. 21.6 g, 21.7 g, P=0.009). Groups 1 and 2 showed similar changes in body weight. Tumor xenografts from IP6-fed mice showed significantly decreased cancer formation and growth, but increased toxicity was noted for high doses of IP6.
CONCLUSION
These results indicate that in the future, IP6 could be an effective chemopreventive or chemotherapeutic agent for use in the treatment of colon cancer.

Related articles
Ann Coloproctol : Annals of Coloproctology Twitter Facebook
© Korean Society of Coloproctology.
TOP