Immunohistochemieal Study of Expression of nm23 and CD44 Protein in.

, Shin, Dong Il; , Lee, Kee Hyung; , Yoon, Choong; , Lee, Ju Hie

Original Article

Journal of the Korean Society of Coloproctology 1997;13(1):15-22.

Shin, Dong Il , Lee, Kee Hyung , Yoon, Choong , Lee, Ju Hie

¹Department of Surgery, Kyung-Hee University Hospital, Seoul, Korea.
²Department of Pathology, Kyung-Hee University Hospital, Seoul, Korea.

Abstract

Gene expression of the nm23 and CD44 has been investigated in number of tumors, in cluding colorectal cancer, breast cancer, and hepatocellular carcinoma. This study was conducted to clarify the association between nm23 and CD44 protein expression and metastatic potential in human colorectal cancer. To elucidate the role of the nm23 and CD44 in human colorectal cancer, sections of formalin-fixed, paraffin-embeded tissue from 59 primary colorectal cancer were stained immunohistochemically against nm23 and CD44 proteins. Expression of the nm23 protein is not significantly correlate with Dukes'stage and recurrence. However, the expression of the CD44 protein is significantly higher in Dukes stage C as comparing with stage B.

Key Words: Colorectal Neoplasms; nm23 H1 Protein; Recurrence