The Effects of Preoperative Pain Education on the Decision to Discharge Patients Following Single-Incision Laparoscopic Appendectomy

Ji Won Seo; Moon Jin Kim; Sung-Hoon Yoon; Kwang Yeol Paik; Sun Min Park; Won Kyung Kang; Dosang Lee; Chul Seung Lee

doi:10.3393/ac.2020.01.16

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Original Article The Effects of Preoperative Pain Education on the Decision to Discharge Patients Following Single-Incision Laparoscopic Appendectomy: Ji Won Seo¹, Moon Jin Kim², Sung-Hoon Yoon³, Kwang Yeol Paik⁴, Sun Min Park⁴, Won Kyung Kang⁴, Dosang Lee¹, Chul Seung Lee¹; Annals of Coloproctology 2020;36(6):398-402.
DOI: https://doi.org/10.3393/ac.2020.01.16
Published online: January 24, 2020

¹Department of Surgery, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea

²Department of Surgery, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Incheon, Korea

³Department of Surgery, St. Vincent Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea

⁴Department of Surgery, Yeoiudo St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea

Correspondence to: Chul Seung Lee, M.D. Division of Colorectal Surgery, Department of Surgery, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, 222 Banpodaero, Seocho-gu, Seoul 06591, Korea Tel: +82-2-2258-6095, Fax: +82-2-595-2282 E-mail: lcscolonoscopy@gmail.com

• Received: December 8, 2019 • Accepted: January 16, 2020

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Abstract
INTRODUCTION
METHODS
RESULTS
DISCUSSION
ARTICLE INFORMATION
SUPPLEMENTARY MATERIAL
REFERENCES

Abstract

Purpose
Few studies have analyzed the effects of preoperative pain education on the postoperative decision to discharge. The purpose of this study was to determine the effects of pain education and management on the decision to discharge patients after single-incision laparoscopic appendectomy (SILA).
Methods
We analyzed 135 patients who had undergone SILA for acute appendicitis between March 2017 and April 2018 in a single medical center. Of these, 72 patients (53.3%) had received preoperative pain education (group 1), and 63 (46.7%) had not (group 2). We compared perioperative outcomes and complications between the groups.
Results
Baseline characteristics of sex, age, body mass index, American Society of Anesthesiologist score, and systemic inflammation factors (neutrophil-lymphocyte ratio, C-reactive protein level) did not differ significantly between the groups. There were no postoperative complications for patients in either group. Perioperative consequences and pathologic findings were not significantly different between the groups; however, length of hospital was significantly shorter in group 1.
Conclusion
Preoperative pain education in relation to postoperative pain management influenced the decision to shorten the postoperative hospital length of stay after SILA.
Keywords: Abdominal pain; Appendectomy; Laparoscopy; Postoperative pain

INTRODUCTION

Several studies have described the advantages of laparoscopic surgery [1-4], and laparoscopic appendectomy has subsequently emerged as a popular procedure with significantly less postoperative pain, a shorter hospital stay, and a faster return to normal activities than the conventional procedure [5]. The single-incision laparoscopic appendectomy (SILA) technique has been developed and adopted by surgeons due to patient preference [6-11]. Moreover, in addition to patient cosmetic and psychological satisfaction, this technique has been shown to lead to a reduced length of hospital stay [7].

Factors likely to affect the length of hospital stay after laparoscopic appendectomy are postoperative pain, fever, nausea and vomiting, leukocytosis, whether the appendix was perforated, and preoperative position of the appendix. Conventional colorectal resection is associated with postoperative pain and long-term fatigue [12]. Pain education as well as postoperative pain management are critical for patient toleration of postoperative pain and for recovery. One study reported that preoperative education on pain reduced the requirement for pain relief [13].

Precise knowledge of the extent of postoperative pain is essential when deciding whether patients are to be discharged from the hospital. This study aimed to investigate the effects of preoperative pain education on determining discharge date after surgery.

METHODS

Patients

We retrospectively collected data from patients who had undergone appendectomy due to appendicitis from March 2017 to April 2018 at Department of Surgery, The Catholic University of Korea, Yeouido St. Mary’s Hospital, Seoul in Korea. In total, 192 patients underwent laparoscopic appendectomy; 57 of whom had undergone 3-port appendectomy, also known as conventional laparoscopic appendectomy (CLA), whereas the remaining 135 patients had undergone single-port appendectomy, also known as SILA. Of the 135 patients who had undergone SILA, 72 were educated before surgery regarding postoperative pain (group 1), whereas 63 patients were not (group 2). Our study was approved by the Institutional Review Board (IRB) of The Catholic University of Korea (SC20RISI0005). Informed consent from patients to be included in this study was omitted according to the policy of our IRB.

The surgeon provided pain education about pain severity and type (wound pain, visceral pain, or somatic pain) and a pain control plan to the chosen patients. We informed patients of the discharge criteria and the methods used to control pain postoperatively, such as oral medication or intravenous medication (Table 1). Moreover, patients were informed that pain severity could be reduced and managed postoperatively during the hospital stay.

Laparoscopic appendectomy was performed for patients with both simple and complicated appendicitis, such as perforated appendicitis, abscess formation, and gangrenous appendicitis. Patients aged < 15 years old and pregnant women were excluded from the study. Intravenous second-generation cephalosporin was administered to all patients prior to induction of anesthesia. Discharge criteria comprised stable vital signs without fever (< 37.8º), tolerance of diet, ability to walk unassisted, and a tolerable visual analogue scale (VAS) score < 3.

Technique

All surgeries were performed by general surgical specialists at The Catholic University of Korea, Yeoido St. Mary’s Hospital. Under general anesthesia, patients were placed in a supine position to the left of the monitor, opposite the surgeon’s position. A 1.0 to 1.5- cm-long vertical umbilical incision was made with dissection to the peritoneum. The commercial Glove port (431AT-2W, Nelis, Bucheon, Korea) was inserted through the umbilical incision, and a rigid 5-mm laparoscope was used. The subsequent surgical procedure and instruments used were the same for SILA and CLA techniques. The resected appendix was removed through the wound retractor. Appropriate irrigation with saline and hemostasis was ensured. In cases with appendiceal perforation or abscess formation, additional extensive irrigation was performed. A drain was inserted in the suprapubic or right lower quadrant area via the incisional wound when drainage was required. The umbilical fascia was closed with Vicryl 1.0 (Ethicon Inc., Cincinnati, OH, USA). The skin incision was closed in subcuticular fashion using Vicryl 4.0 (Ethicon Inc.) and steri-strips (3M HealthCare, St. Paul, MN, USA) were applied to the umbilicus.

Statistical analysis

Statistical analysis was performed using IBM SPSS Statistics (ver. 24.0, IBM Corp., Armonk, NY, USA). Student t-test or Pearson chi-square and Fisher exact tests were used for between-group comparisons based on data type and distribution. Significant associations obtained on univariate analysis were included in a multivariable logistic regression analysis to identify independent predictors of postoperative hospital stay. For all analyses, a P-value< 0.05 was considered statistically significant.

RESULTS

The SILA technique was performed on 135 patients. There was no significant difference in patient demographics of sex, age, American Society of Anesthesiologists (ASA) physical status classification, body mass index (BMI), and rate of complicated appendicitis between groups 1 and 2 (Table 2). The mean patient age in groups 1 and 2 was 39.2± 15.5 years and 40.7± 13.6 years, respectively (P = 0.549). The mean BMI in groups 1 and 2 was 23.2 ± 3.3 kg/m² and 23.4 ± 4.0 kg/m², respectively (P = 0.781). The rate of complicated appendicitis in groups 1 and 2 was 37.5% (27/72) and 22.2% (14/63), respectively.

Comparing perioperative outcomes, start (day) of soft diet was not significantly different between group 1 (1.2± 0.48 days) and group 2 (1.2 ± 0.45 days) (P = 0.749). The median VAS score 24-hours postoperatively was not significantly different between group 1 (3.3± 1.8) and group 2 (3.1± 1.7) (P= 0.730). The maximum VAS score during the 24-hour postoperative period was not significantly different between group 1 (5.8 ± 2.0) and group 2 (6.3± 1.6) (P= 0.110).

Postoperative hospital stay was shorter in group 1 (1.9± 0.97) than in group 2 (2.9± 1.6) (P< 0.001). Between the groups, postoperative complications and readmission rates were not significantly different. There was no occurrence of severe complications, defined using the Clavien-Dindo classification as morbidity grade > III, in either group nor were there any postoperative deaths (Table 3).

In univariate analyses, pain education and complicated appendicitis on initial computed tomography were significantly associated with delayed postoperative hospital length of stay. Moreover, in multivariable analysis, lack of preoperative pain information (P< 0.001) and preoperative diagnosis of complicated appendicitis (P= 0.001) were independent risk factors for longer postoperative hospital stay (P< 0.001; Table 4).

DISCUSSION

Information concerning discharge criteria, surgical procedure, and postoperative patient management was obtained for all study patients. Both a specialist and a surgical resident participated in each surgical procedure, with the surgical resident being present for longer than half the operation time. No significant difference was found between groups in terms of sex, age, ASA physical status classification, BMI, and rate of complicated appendicitis; however, we observed a significant difference in length of hospital stay. Group 1 patients, who had received preoperative pain education, showed significantly reduced hospital stay compared to patients in group 2, who had not received preoperative pain education.

Single-port or 3-port appendectomy was performed according to the surgeon’s preference. In cases of severe inflammation of the terminal ileum or cecum or generalized panperitonitis, a 3-port laparoscopy should be performed. To reduce heterogeneity due to surgical method, we excluded patients who underwent 3-port surgery and compared only patients who had undergone single-port surgery.

Our institution is a tertiary referral medical center; therefore, patients with simple appendicitis were often transferred to a local clinic when there are few surgeons or anesthetists. However, patients with severe appendicitis, such as complicated appendicitis, were likely to undergo surgery at our hospital. Therefore, the rate of complicated appendicitis was relatively high compared to that in other medical centers, where the rate has been reported to be < 10% [14].

Introduction of diagnosis-related group (DRG) systems where hospitals cover medical cost payments for patients undergoing appendectomy has been shown to reduce significantly the economic burden for patients in relation to medical costs nationwide [15]. Despite patients with appendectomy staying longer in hospital compared to the average length of hospital stay, their costs tend not to increase due to the DRG system [16]. However, some patients decline postoperative discharge from the hospital until complete recovery, despite lack of pain and fatigue. Our findings that preoperative pain education regarding postoperative pain and management affect length of patient hospital stay may reduce the number of such patients.

Some studies have reported on postoperative pain education, as this topic has emerged as an important issue [12, 13]. Patient education usually includes information concerning pain and its management and refers to all educational activities directed at patients and/or their families. Patient education aims to establish patient competence and confidence in undertaking health behaviors that are consistent with life plans and that support autonomous decision-making, whereby patient learning is assisted by an educator’s teaching strategies and selected instructional material. In relevant studies, this education process has typically comprised 4 steps: (1) assessment of patient educational needs and potential barriers to learning; (2) setting educational objectives; (3) implementation using instructional methods and tools; and (4) evaluation of patient learning [17]. However, few studies have reported preoperative pain education for patients undergoing emergency surgery.

Our preoperative education program for patients included the following content regarding postoperative pain, pain control planning, effective pain control, and discharge criteria: “(1) You may feel more pain immediately after the surgery, but the pain will gradually decrease and will eventually desist; (2) Because the surgery is a single-port procedure, the pain will be concentrated at the umbilicus, and you will feel more pain than that experienced after a 3-port procedure; (3) For VAS score > 4, you may be injected with an intravenous painkiller or you may be allowed to take a painkiller orally when you are capable of eating; and (4) You may be discharged if you can control your pain with oral medications alone.” This education program aimed to provide patients in group 1 with a better understanding of postoperative pain and more appropriate postoperative pain control than those in group 2. The incidence of pain attributable to vague anxiety may be reduced by including the expected degree of pain among the discharge criteria described in the educational contents, which may consecutively reduce eventual delays in discharge.

Most patients in group 2 rejected discharge due to surgical site pain (VAS score < 3). They mentioned that they were afraid of pain exacerbation when they returned home. Some patients who lived far from our hospital rejected discharge because they needed to arrange public transportation according to the train and express bus schedules. Furthermore, patients who had no family and lived alone refused to be discharged because they had no one to take care of them at home.

Factors affecting the decision to discharge a patient include patient level of consciousness, physical activity, hemodynamic stability, respiratory stability, postoperative pain assessment, and postoperative emetic symptoms. In univariate analysis, operation time and pain education were significant factors affecting hospital length of stay; in multivariable analysis, preoperative pain education was an independent factor affecting hospital length of stay.

This study had some limitations. First, this was a retrospective study with a small number of patients. Therefore, large-scale multi-center studies or a randomized control trial should be conducted to more clearly identify the factors related to hospital length of stay. Second, we did not analyze hourly pain score or quality of life between the 2 groups. Nevertheless, this study revealed a clear correlation between preoperative pain education and shortened hospital length of stay. Finally, other risk factors of postoperative pain, such as surgical incision length, were not measured. Nevertheless, all procedures were performed by experienced surgeons, and all incisions were made in the umbilicus. Surgical procedures, including the wound closure technique, did not vary.

In conclusion, preoperative pain education in relation to postoperative pain management for patients with appendicitis shortened the postoperative hospital length of stay.

ARTICLE INFORMATION

CONFLICT OF INTEREST

No potential conflict of interest relevant to this article was reported.

SUPPLEMENTARY MATERIAL

Supplementary materials for this study are presented online (available at https://doi.org/10.3393/ac.2020.01.16).

Supplementary data

ac-2020-01-16-suppl1.pdf

Table 1.

Pain instructions for single-incision laparoscopic appendectomy

Preoperative	Intraoperative	Postoperative
Patient counseling and education^a		Aceclofenac 100 mg, every 12 hr
Patient counseling and education^a		Ketolac 30 mg IV as needed
Ketolac 30 mg IV	Ramosetron HCI 0.3 mg	If inadequate → tridol 50 mg IV
Ketolac 30 mg IV		If inadequate → pethidine 25 mg IV

IV, intravenously.

^aOnly group 1, see Supplementary data.

Table 2.

Patient demographics

Variable	Group 1 (n = 72)	Group 2 (n = 63)	P-value
Sex (male/female)	34/38	32/31	0.405
Age (yr)	39.2 ± 15.5	40.7 ± 13.6	0.549
ASA PS classification (%)			0.301
I	67 (93.1)	62 (98.4)
II	4 (5.6)	1 (1.6)
III	1 (1.4)	0 (0)
Body mass index (kg/m²)	23.2 ± 3.3	23.4 ± 4.0	0.781
Diagnosis (%)
Suppurative^a	51 (70.8)	49 (77.8)	0.358
Perforated^b	14 (19.4)	7 (11.1)	0.183
Gangrenous^c	11 (15.3)	15 (23.8)	0.620
Abscess^d	8 (11.1)	5 (7.9)	0.533
Preoperative WBC (/μL)	12,549.2 ± 4,206.4	12,348.4 ± 3,722.5	0.367
Preoperative CRP (mg/L)	26.7 ± 44.2	25.6 ± 46.3	0.932
Complicated appendicitis^e	27 (37.5)	14 (22.2)	0.054

Values are presented as number only, mean±standard deviation, or number (%).

Group 1, patients with preoperative pain education; group 2, patients without preoperative pain education.

ASA PS, American Society of Anesthesiologists physical status; WBC, white blood cell; CRP, C-reactive protein.

^aSuppurative appendicitis.

^bPerforated appendicitis.

^cGangrenous appendicitis.

^dPeriappendiceal abscess.

^eComplicated appendicitis included perforation, peritonitis, and/or abscess.

Table 3.

Perioperative outcomes

Variable	Group 1 (n = 72)	Group 2 (n = 63)	P-value
Operative time (min)			0.213
> 60	15 (20.8)	19 (30.2)
≤ 60	57 (79.2)	44 (69.8)
Drain	3 (4.2)	5 (7.9)	0.287
Postoperative hospital stay (day)	1.9 ± 0.97	2.9 ± 1.6	< 0.001
Start of soft diet (postoperative day)	1.2 ± 0.48	1.2 ± 0.45	0.749
VAS until postoperative day 1
Median	3.3 ± 1.8	3.1 ± 1.7	0.730
Max	5.8 ± 2.0	6.3 ± 1.6	0.110
Superficial incisional SSI	1 (1.4)	3 (4.8)	0.249
Organ space SSI	0 (0)	0 (0)	-
Ileus	2 (2.8)	0 (0)	0.183
Severe complication^a	0 (0)	0 (0)	-
Reoperation	0 (0)	0 (0)	-
Readmission within 30 days	0 (0)	0 (0)	-
Mortality within 30 days	0 (0)	0 (0)	-

Values are presented as number (%) or mean±standard deviation.

Group 1, patients with preoperative pain education; group 2, patients without preoperative pain education.

VAS, visual analogue scale for pain; SSI, surgical site infection.

^aClavien-Dindo classification ≥IIIa.

Table 4.

Predictors of postoperative hospital stay (>2 days) after single-incision appendectomy in univariable and multivariable logistic regression analyses

Variable	Univariate analysis		Multivariate analysis
Variable	OR (95% CI)	P-value	OR (95% CI)	P-value
Age (> 65 yr)	1.78 (0.38–8.31)	0.466	NA
Female sex	1.01 (0.48–2.10)	0.987	NA
Body mass index (> 25 kg/m²)	1.06 (0.45–2.49)	0.773	NA
Operative time (> 60 min)	1.13 (0.49–2.61)	0.773	NA
Complicated appendicitis^a	2.42 (1.11–5.25)	0.026	5.90 (2.03–17.19)	0.001
Preoperative WBC (> 12,000/μL)	0.16 (0.28–1.24)	0.591	NA
Preoperative CRP (> 10 mg/L)	1.47 (0.70–3.07)	0.309	NA
Pain instruction (no)	7.23 (3.07–17.00)	< 0.001	13.17 (4.53–38.22)	< 0.001

OR, odds ratio; CI, confidence interval; NA, not applicable; WBC, white blood cell; CRP, C-reactive protein.

^aComplicated appendicitis included perforation, peritonitis, and/or abscess.

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The Effects of Preoperative Pain Education on the Decision to Discharge Patients Following Single-Incision Laparoscopic Appendectomy

Ann Coloproctol. 2020;36(6):398-402. Published online January 24, 2020

DOI: https://doi.org/10.3393/ac.2020.01.16

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The Effects of Preoperative Pain Education on the Decision to Discharge Patients Following Single-Incision Laparoscopic Appendectomy

Preoperative	Intraoperative	Postoperative
Patient counseling and education^a		Aceclofenac 100 mg, every 12 hr
Patient counseling and education^a		Ketolac 30 mg IV as needed
Ketolac 30 mg IV	Ramosetron HCI 0.3 mg	If inadequate → tridol 50 mg IV
Ketolac 30 mg IV		If inadequate → pethidine 25 mg IV

Variable	Group 1 (n = 72)	Group 2 (n = 63)	P-value
Sex (male/female)	34/38	32/31	0.405
Age (yr)	39.2 ± 15.5	40.7 ± 13.6	0.549
ASA PS classification (%)			0.301
I	67 (93.1)	62 (98.4)
II	4 (5.6)	1 (1.6)
III	1 (1.4)	0 (0)
Body mass index (kg/m²)	23.2 ± 3.3	23.4 ± 4.0	0.781
Diagnosis (%)
Suppurative^a	51 (70.8)	49 (77.8)	0.358
Perforated^b	14 (19.4)	7 (11.1)	0.183
Gangrenous^c	11 (15.3)	15 (23.8)	0.620
Abscess^d	8 (11.1)	5 (7.9)	0.533
Preoperative WBC (/μL)	12,549.2 ± 4,206.4	12,348.4 ± 3,722.5	0.367
Preoperative CRP (mg/L)	26.7 ± 44.2	25.6 ± 46.3	0.932
Complicated appendicitis^e	27 (37.5)	14 (22.2)	0.054

Variable	Group 1 (n = 72)	Group 2 (n = 63)	P-value
Operative time (min)			0.213
> 60	15 (20.8)	19 (30.2)
≤ 60	57 (79.2)	44 (69.8)
Drain	3 (4.2)	5 (7.9)	0.287
Postoperative hospital stay (day)	1.9 ± 0.97	2.9 ± 1.6	< 0.001
Start of soft diet (postoperative day)	1.2 ± 0.48	1.2 ± 0.45	0.749
VAS until postoperative day 1
Median	3.3 ± 1.8	3.1 ± 1.7	0.730
Max	5.8 ± 2.0	6.3 ± 1.6	0.110
Superficial incisional SSI	1 (1.4)	3 (4.8)	0.249
Organ space SSI	0 (0)	0 (0)	-
Ileus	2 (2.8)	0 (0)	0.183
Severe complication^a	0 (0)	0 (0)	-
Reoperation	0 (0)	0 (0)	-
Readmission within 30 days	0 (0)	0 (0)	-
Mortality within 30 days	0 (0)	0 (0)	-

Variable	Univariate analysis		Multivariate analysis
Variable	OR (95% CI)	P-value	OR (95% CI)	P-value
Age (> 65 yr)	1.78 (0.38–8.31)	0.466	NA
Female sex	1.01 (0.48–2.10)	0.987	NA
Body mass index (> 25 kg/m²)	1.06 (0.45–2.49)	0.773	NA
Operative time (> 60 min)	1.13 (0.49–2.61)	0.773	NA
Complicated appendicitis^a	2.42 (1.11–5.25)	0.026	5.90 (2.03–17.19)	0.001
Preoperative WBC (> 12,000/μL)	0.16 (0.28–1.24)	0.591	NA
Preoperative CRP (> 10 mg/L)	1.47 (0.70–3.07)	0.309	NA
Pain instruction (no)	7.23 (3.07–17.00)	< 0.001	13.17 (4.53–38.22)	< 0.001

Table 1. Pain instructions for single-incision laparoscopic appendectomy

IV, intravenously.

Only group 1, see Supplementary data.

Table 2. Patient demographics

Values are presented as number only, mean±standard deviation, or number (%).

Group 1, patients with preoperative pain education; group 2, patients without preoperative pain education.

ASA PS, American Society of Anesthesiologists physical status; WBC, white blood cell; CRP, C-reactive protein.

Suppurative appendicitis.

Perforated appendicitis.

Gangrenous appendicitis.

Periappendiceal abscess.

Complicated appendicitis included perforation, peritonitis, and/or abscess.

Table 3. Perioperative outcomes

Values are presented as number (%) or mean±standard deviation.

Group 1, patients with preoperative pain education; group 2, patients without preoperative pain education.

VAS, visual analogue scale for pain; SSI, surgical site infection.

Clavien-Dindo classification ≥IIIa.

Table 4. Predictors of postoperative hospital stay (>2 days) after single-incision appendectomy in univariable and multivariable logistic regression analyses

OR, odds ratio; CI, confidence interval; NA, not applicable; WBC, white blood cell; CRP, C-reactive protein.