Ann Coloproctol > Volume 39(6); 2023 > Article |
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Author contributions
Conceptualization: JSK; Data curation: JHS, RKO, JEL, KHL; Formal analysis: KHL, JYK; Investigation: JHS, RKO, JEL, JSK; Methodology: JHS, JEL; Project administration: JYK, JSK; Supervision: KHL, JYK; Validation: all authors; Visualization: all authors; Writing–original draft: JHS; Writing–review & editing: all authors. All authors read and approved the final manuscript.
Characteristic |
Presarcopenia |
||
---|---|---|---|
No (n=244) | Yes (n=57) | P-value | |
Area of skeletal muscle (cm2) | 134.97±25.69 | 108.24±24.28 | <0.001 |
Area of visceral fat (cm2) | 129.80±70.0 | 135.68±80.06 | 0.579 |
Area of subcutaneous fat (cm2) | 104.79±57.55 | 114.85±55.26 | 0.232 |
Preoperative hemoglobin (g/dL) | 13.07±1.81 | 12.52±1.63 | 0.034 |
Preoperative albumin (g/dL) | 4.06±0.44 | 4.01±0.40 | 0.461 |
Initial CEA (ng/mL) (n=293)a | 7.40±23.58 | 5.55±8.56 | 0.560 |
Time to first flatus (day) | 1.94±1.01 | 3.09±1.80 | <0.001 |
Time to tolerable soft diet (day) | 4.39±3.25 | 4.30±3.46 | 0.857 |
Length of hospital stay (day) | 11.55±11.37 | 9.84±6.48 | 0.277 |
Postoperative complication | 69 (28.3) | 21 (36.8) | 0.204 |
Clavien-Dindo classification (grade III or IV) | 36 (14.8) | 5 (8.8) | 0.236 |
Factor | No. of patients (n=301) |
Overall survival |
Disease-free survival |
||
---|---|---|---|---|---|
% | P-value | % | P-value | ||
Age (yr) | <0.001 | 0.311 | |||
<70 | 198 | 90.5 | 89.8 | ||
≥70 | 103 | 72.3 | 85.7 | ||
Sex | 0.059 | 0.504 | |||
Male | 193 | 84.3 | 87.9 | ||
Female | 108 | 84.9 | 90.4 | ||
Body mass index (kg/m2) | 0.222 | 0.306 | |||
<25 | 193 | 85.1 | 90.0 | ||
≥25 | 108 | 83.5 | 85.6 | ||
Comorbidity | 0.240 | 0.586 | |||
No | 159 | 86.6 | 89.2 | ||
Yes | 142 | 84.6 | 87.7 | ||
Presarcopenia | 0.460 | 0.603 | |||
No | 244 | 87.7 | 88.9 | ||
Yes | 57 | 66.5 | 90.6 | ||
Preoperative chemoradiotherapy | 0.206 | 0.010 | |||
No | 225 | 87.2 | 91.4 | ||
Yes | 76 | 68.7 | 79.7 | ||
Initial CEA (ng/mL) (n=293)a | 0.050 | 0.208 | |||
<5 | 216 | 88.6 | 89.9 | ||
≥5 | 77 | 68.5 | 84.7 | ||
ASA physical status | 0.029 | 0.207 | |||
I, II | 270 | 88.5 | 89.0 | ||
III, IV | 31 | 58.7 | 96.0 | ||
Abdominoperineal resection | 0.002 | 0.055 | |||
No | 289 | 89.1 | 90.8 | ||
Yes | 12 | 40.0 | 70.0 | ||
Histology | 0.459 | 0.808 | |||
WD or MD | 285 | 88.8 | 90.6 | ||
PD or mucinous | 16 | 74.0 | 86.7 | ||
Pathologic T | <0.001 | <0.001 | |||
T0–T2 | 172 | 93.7 | 93.7 | ||
T3–T4 | 129 | 74.8 | 81.3 | ||
Pathologic N | 0.001 | 0.004 | |||
N0 | 207 | 91.5 | 92.0 | ||
N+ | 94 | 68.5 | 80.8 | ||
Adjuvant chemotherapy | 0.077 | 0.139 | |||
No | 146 | 91.9 | 87.4 | ||
Yes | 155 | 85.2 | 83.9 |
Factor | No. of patients (n=293)a |
Overall survival |
No. of patients (n=301) |
Disease-free survival |
||
---|---|---|---|---|---|---|
HR (95% CI) | P-value | HR (95% CI) | P-value | |||
Age (yr) | 0.008 | - | - | - | ||
<70 | 191 | 1 (Reference) | ||||
≥70 | 102 | 2.200 (1.223–3.959) | ||||
Sex | 0.013 | - | - | - | ||
Female | 105 | 1 (Reference) | ||||
Male | 188 | 2.239 (1.184–4.236) | ||||
Initial CEA (ng/mL) | 0.442 | - | - | - | ||
<5 | 216 | 1 (Reference) | ||||
≥5 | 77 | 1.263 (0.697–2.289) | ||||
Preoperative chemoradiotherapy | - | - | - | 0.009 | ||
No | 255 | 1 (Reference) | ||||
Yes | 76 | 2.709 (1.276–5.750) | ||||
ASA physical status | 0.095 | - | - | - | ||
I, II | 263 | 1 (Reference) | ||||
III, IV | 30 | 1.824 (0.900–3.694) | ||||
Abdominoperineal resection | 0.021 | 0.306 | ||||
No | 281 | 1 (Reference) | 289 | 1 (Reference) | ||
Yes | 12 | 2.969 (1.181–7.466) | 12 | 1.917 (0.551–6.669) | ||
Pathologic T | 0.004 | 0.026 | ||||
T0–T2 | 167 | 1 (Reference) | 172 | 1 (Reference) | ||
T3–T4 | 126 | 2.624 (1.351–5.098) | 129 | 2.539 (1.115–5.781) | ||
Pathologic N | 0.332 | 0.055 | ||||
N0 | 200 | 1 (Reference) | 207 | 1 (Reference) | ||
N+ | 93 | 1.360 (0.731–2.531) | 94 | 2.166 (0.985–4.764) | ||
Adjuvant chemotherapy | 0.995 | 0.722 | ||||
Yes | 154 | 1 (Reference) | 155 | 1 (Reference) | ||
No | 139 | 1.002 (0.542–1.853) | 146 | 1.155 (0.523–2.547) |
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